Prognostic Values of METTL3 and Its Roles in Tumor Immune Microenvironment in Pan-Cancer.

ABSTRACT: Background: N6-methyladenosine (m⁶A) is among the most prevalent RNA modifications regulating RNA metabolism. The roles of methyltransferase-like 3 (METTL3), a core catalytic subunit, in various cancers remain unclear. Methods: The expression levels of METTL3 in pan-cancer were profiled and their prognostic values were examined. We assessed the relationships between METTL3 expression levels and tumor immune infiltration levels, immune checkpoint gene expression, immune neoantigens, tumor mutation burden, microsatellite instability, and DNA mismatch repair gene expression. Furthermore, a protein-protein interaction network was drawn, and gene set enrichment analysis was conducted to explore the functions of METTL3. Results: METTL3 expression levels were eleva

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9821157 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature