Progress in the Structural Basis of thermoTRP Channel Polymodal Gating.

ABSTRACT: The thermosensory transient receptor potential (thermoTRP) family of ion channels is constituted by several nonselective cation channels that are activated by physical and chemical stimuli functioning as paradigmatic polymodal receptors. Gating of these ion channels is achieved through changes in temperature, osmolarity, voltage, pH, pressure, and by natural or synthetic chemical compounds that directly bind to these proteins to regulate their activity. Given that thermoTRP channels integrate diverse physical and chemical stimuli, a thorough understanding of the molecular mechanisms underlying polymodal gating has been pursued, including the interplay between stimuli and differences between family members. Despite its complexity, recent advances in cryo-electron microscopy techniques are f

SUBMITTER: Fernandez-Ballester G 

PROVIDER: S-EPMC9821180 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature