Evaluation of (R)-[¹¹C]PK11195 PET/MRI for Spinal Cord-Related Neuropathic Pain in Patients with Cervical Spinal Disorders.

ABSTRACT: Activated microglia are involved in secondary injury after acute spinal cord injury (SCI) and in development of spinal cord-related neuropathic pain (NeP). The aim of the study was to assess expression of translocator protein 18 kDa (TSPO) as an indicator of microglial activation and to investigate visualization of the dynamics of activated microglia in the injured spinal cord using PET imaging with (R)-[¹¹C]PK11195, a specific ligand for TSPO. In SCI chimeric animal models, TSPO was expressed mainly in activated microglia. Accumulation of (R)-[³H]PK11195 was confirmed in autoradiography and its dynamics in the injured spinal cord were visualized by (R)-[¹¹C]PK11195 PET imaging in the acute phase after SCI. In clinical application of

SUBMITTER: Kitade M 

PROVIDER: S-EPMC9821277 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature