Strategies to Overcome Resistance to Immune-Based Therapies in Osteosarcoma.

ABSTRACT: Improving the prognosis and cure rate of HGOSs (high-grade osteosarcomas) is an absolute need. Immune-based treatment approaches have been increasingly taken into consideration, in particular for metastatic, relapsed and refractory HGOS patients, to ameliorate the clinical results currently achieved. This review is intended to give an overview on the immunotherapeutic treatments targeting, counteracting or exploiting the different immune cell compartments that are present in the HGOS tumor microenvironment. The principle at the basis of these strategies and the possible mechanisms that HGOS cells may use to escape these treatments are presented and discussed. Finally, a list of the currently ongoing immune-based trials in HGOS is provided, together with the results that have been obtained

SUBMITTER: Hattinger CM 

PROVIDER: S-EPMC9821333 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature