The need for blood transfusion therapy is associated with increased mortality in children with traumatic brain injury.

ABSTRACT:

Objective

Blood transfusion therapy (BTT) is widely used in trauma patients. However, the adverse effects of BTT in pediatric trauma patients with traumatic brain injury (TBI) were poorly studied. The objective of this study is to evaluate the effect of BTT on mortality in children with severe TBI.

Methods

In this retrospective cohort analysis, we analyzed 2012 and 2016 Kids' Inpatient Databases and used a weighted sample to obtain national outcome estimates. We included children aged 1 month to 21 years with TBI who were mechanically ventilated, considered severe TBI; we then compared the demographics, comorbidities, and mortality rates of those patients who had undergone BTT to those who did not. Statistical analysis was performed using the chi-squared test and regression

SUBMITTER: Chegondi M 

PROVIDER: S-EPMC9821419 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature