Predicting tolerability of high-dose fentanyl buccal tablets in cancer patients.

ABSTRACT:

Background & aims

Fentanyl buccal tablets (FBTs) are a rapid-onset opioid indicated for breakthrough cancer pain (BTcP) and FBT titration is needed to optimize BTcP management. We aimed to predict which patients could tolerate a high dose of FBT (400 μg or more at a time).

Methods

A retrospective analysis was performed to assess the final FBT dose. The final FBT doses were compared according to the clinical features. The prediction accuracy of patients tolerant of 400 μg or higher FBT was compared using the area under the receiver operating characteristic (ROC) curves. A risk scoring model based on the odds ratio (OR) was developed from the final multivariable model, and patients were assigned into two groups: low tolerance (0-1 point) and high tolerance (2-3 points).

Res

SUBMITTER: Kwon MY 

PROVIDER: S-EPMC9821425 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature