Expression of virulence and antimicrobial related proteins in Burkholderia mallei and Burkholderia pseudomallei.

ABSTRACT:

Background

Burkholderia mallei and Burkholderia pseudomallei are both potential biological threat agents. Melioidosis caused by B. pseudomallei is endemic in Southeast Asia and Northern Australia, while glanders caused by B. mallei infections are rare. Here we studied the proteomes of different B. mallei and B. pseudomallei isolates to determine species specific characteristics.

Methods

The expressed proteins of 5 B. mallei and 6 B. pseudomallei strains were characterized using liquid chromatography high-resolution tandem mass spectrometry (LC-HRMS/MS). Subsequently, expression of potential resistance and virulence related characteristics were analyzed and compared.

Results

Proteome analysis can be used for the identification of B. mallei and B. pseudomallei. Both spe

SUBMITTER: Paauw A 

PROVIDER: S-EPMC9821509 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature