A quantitative model for human neurovascular coupling with translated mechanisms from animals.

ABSTRACT: Neurons regulate the activity of blood vessels through the neurovascular coupling (NVC). A detailed understanding of the NVC is critical for understanding data from functional imaging techniques of the brain. Many aspects of the NVC have been studied both experimentally and using mathematical models; various combinations of blood volume and flow, local field potential (LFP), hemoglobin level, blood oxygenation level-dependent response (BOLD), and optogenetics have been measured and modeled in rodents, primates, or humans. However, these data have not been brought together into a unified quantitative model. We now present a mathematical model that describes all such data types and that preserves mechanistic behaviors between experiments. For instance, from modeling of optogenetics and micro

SUBMITTER: Sten S 

PROVIDER: S-EPMC9821752 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature