Electroanalysis of Ibuprofen and Its Interaction with Bovine Serum Albumin.

ABSTRACT: The current work presents a sensitive, selective, cost-effective, and environmentally benign protocol for the detection of ibuprofen (IBP) by an electrochemical probe made of a glassy carbon electrode modified with Ag-ZnO and MWCNTs. Under optimized conditions, the designed sensing platform was found to sense IBP up to a 28 nM limit of detection. The interaction of IBP with bovine serum albumin (BSA) was investigated by differential pulse voltammetry. IBP-BSA binding parameters such as the binding constant and the stoichiometry of complexation were calculated. The results revealed that IBP and BSA form a single strong complex with a binding constant value of 8.7 × 10¹³. To the best of our knowledge, this is the first example that reports not only IBP detection but also its BSA complexation.

SUBMITTER: Dilshad M 

PROVIDER: S-EPMC9821973 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature