Biological Activity of Amidino-Substituted Imidazo [4,5-b]pyridines.

ABSTRACT: A series of cyano- and amidino-substituted imidazo[4,5-b]pyridines were synthesized using standard methods of organic synthesis, and their biological activity was evaluated. Biological evaluation included in vitro assessment of antiproliferative effects on a diverse selection of human cancer cell lines, antibacterial activity against chosen Gram-positive and Gram-negative bacterial strains, and antiviral activity on a broad panel of DNA and RNA viruses. The most pronounced antiproliferative activity was observed for compound 10, which contained an unsubstituted amidino group, and compound 14, which contained a 2-imidazolinyl amidino group; both displayed selective and strong activity in sub-micromolar inhibitory concentration range against colon carcinoma (IC₅₀

SUBMITTER: Pavlinac IB 

PROVIDER: S-EPMC9822021 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature