Valorization of Wild-Type Cannabis indica by Supercritical CO₂ Extraction and Insights into the Utilization of Raffinate Biomass.

ABSTRACT: Supercritical CO₂ extraction (SCCO₂) extraction of cannabis oil from Indian cannabis (Cannabis indica) leaves was optimized through a central composite design using CO₂ pressure (150-250 bar), temperature (30-50 °C) and time (1-2 h). From the regression model, the optimal CO₂ pressure, extraction temperature and time were 250 bar, 43 °C and 1.7 h, respectively resulting in the experimental yield of 4.9 wt% of cannabis oil via SCCO₂ extraction. The extract contained cannabidiol, tetrahydrocannabivarin, Δ⁹-tetrahydrocannabinol and Δ⁸-tetrahydrocannabinol as well as two terpenoids such as cis-caryophyllene and α-humulene. Besides SCCO₂ extraction of cannabis oil, the raffinate biomass was utilized t

SUBMITTER: Pattnaik F 

PROVIDER: S-EPMC9822091 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature