The First Snake Venom KTS/Disintegrins-Integrin Interactions Using Bioinformatics Approaches.

ABSTRACT: Snake venom contains a number of active molecules that have been shown to possess high anti-tumor activities; disintegrins are an excellent example among these. Their ability to interact and bind with integrins suggests that they could be very valuable molecules for the development of new cancer therapeutic approaches. However, in the absence of a clear Lysine-Threonine-Serine (KTS) Disintegrins Integrin interaction model, the exact compound features behind it are still unknown. In this study, we investigated the structural characteristics of three KTS-disintegrins and the interaction mechanisms with the α1β1 integrin receptor using in silico bioinformatics approaches. Normal mode analysis showed that the flexibility of the KTSR motif and the C-terminal region play a key role and influence

SUBMITTER: Khamessi O 

PROVIDER: S-EPMC9822126 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature