Effect of Chicken Egg White-Derived Peptide and Hydrolysates on Abnormal Skin Pigmentation during Wound Recovery.

ABSTRACT: Abnormal skin pigmentation commonly occurs during the wound healing process due to the overproduction of melanin. Chicken egg white (CEW) has long been used to improve skin health. Previous published works had found CEW proteins house bioactive peptides that inhibit tyrosinase, the key enzyme of melanogenesis. The current study aimed to evaluate the anti-pigmentation potential and mechanism of the CEW-derived peptide (GYSLGNWVCAAK) and hydrolysates (CEWH_mono and CEWH_di), using a cell-based model. All of these peptide and hydrolysates inhibited intracellular tyrosinase activity and melanin level up to 45.39 ± 1.31 and 70.01 ± 1.00%, respectively. GYSLGNWVCAAK and CEWH_di reduced intracellular cAMP levels by 13.38 ± 3.65 and 14.55 ± 2.82%, respectively; howeve

SUBMITTER: Yap PG 

PROVIDER: S-EPMC9822140 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature