Rapid Determination of Geniposide and Baicalin in Lanqin Oral Solution by Near-Infrared Spectroscopy with Chemometric Algorithms during Alcohol Precipitation.

ABSTRACT: The selection of key variables is an important step that improves the prediction performance of a near-infrared (NIR) real-time monitoring system. Combined with chemometrics, NIR spectroscopy was employed to construct high predictive accuracy, interpretable models for the rapid detection of the alcohol precipitation process of Lanqin oral solution (LOS). The variable combination population analysis-iteratively retaining informative variables (VCPA-IRIV) was innovatively introduced into the variable screening process of the model of geniposide and baicalin. Compared with the commonly used synergy interval partial least squares regression, competitive adaptive reweighted sampling, and random frog, VCPA-IRIV achieved the maximum compression of variable space. VCPA-IRIV-partial least squares r

SUBMITTER: Ma H 

PROVIDER: S-EPMC9822193 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature