Synthesis, Biological Evaluation, DNA Binding, and Molecular Docking of Hybrid 4,6-Dihydrazone Pyrimidine Derivatives as Antitumor Agents.

ABSTRACT: In the present paper, on the basis of molecular hybridization, a series of 4,6-dihydrazone pyrimidine derivatives containing the pyridine moiety were synthesized, structurally characterized, and evaluated in vitro for their antitumor activity. According to the results, all the tested compounds demonstrated broad-spectrum antitumor activity against selected tumor cell lines (MCF-7, BGC-823, A549, and BEL-7402) and no obvious toxicity toward normal cells HL-7702. In particular, compounds 10a and 10f were found to be the most promising antitumor agents among the tested compounds against BGC-823 cells (IC₅₀ = 9.00 μM and 7.89 μM) and BEL-7402 cells (IC₅₀ = 6.70 μM and 7.66 μM), respectively. Compounds 10a and 10f exhibited higher potency agains

SUBMITTER: Lan H 

PROVIDER: S-EPMC9822369 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature