Evaluation of Genotoxicity and Toxicity of Annona muricata L. Seeds and In Silico Studies.

ABSTRACT: Cancer is a multifactorial organic dysfunction for which great efforts are being devoted in searching for new treatments and therapeutic adjuvants. Annona muricata is a fruit that has promising activity against several types of cancer, as it contains acetogenins, the metabolite group associated with this action. Thus, the objective of this study was to evaluate, in experimental models, the toxic behavior of an extract and fraction rich in acetogenins from A. muricata seeds and study the acetogenin, Annonacin, in silico. Phytochemical characterization was made by thin layer chromatography, spectroscopy in the infrared region and nuclear magnetic resonance. Toxicity was evaluated by tests of Allium cepa and Artemia salina, and in silico studies using the SwissDock

SUBMITTER: Ferreira GG 

PROVIDER: S-EPMC9822370 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature