Chemoenzymatic Synthesis of Indole-Containing Acyloin Derivatives.

ABSTRACT: Indole-containing acyloins are either key intermediates of many antimicrobial/antiviral natural products or building blocks in the synthesis of biologically active molecules. As such, access to structurally diverse indole-containing acyloins has attracted considerable attention. In this report, we present a pilot study of using biotransformation to provide acyloins that contain various indole substituents. The biotransformation system contains the tryptophan synthase standalone β-subunit variant, PfTrpB⁶, generated from directed evolution in the literature; a commercially available L-amino acid oxidase (LAAO); and the thiamine-diphosphate (ThDP)-dependent enzyme NzsH, encoded in the biosynthetic gene cluster (nzs) of the bacterial carbazole alkaloid natural product

SUBMITTER: Alrashdi S 

PROVIDER: S-EPMC9822442 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature