Methotrexate recognition by the human reduced folate carrier SLC19A1.

ABSTRACT: Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of amino acids during cell division^1,2. Mammals lack de novo folate synthesis pathways and thus rely on folate uptake from the extracellular milieu³. The human reduced folate carrier (hRFC, also known as SLC19A1) is the major importer of folates into the cell^1,3, as well as chemotherapeutic agents such as methotrexate^4-6. As an anion exchanger, RFC couples the import of folates and antifolates to anion export across the cell membrane and it is a major determinant in methotrexate (antifolate) sensitivity, as genetic variants and its depletion result in drug resistance^4-

SUBMITTER: Wright NJ 

PROVIDER: S-EPMC9822521 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature