Overexpression of Mena is associated with tumor progression and poor prognosis in oral squamous cell carcinoma via EMT.

ABSTRACT:

Background

Mena, a cytoskeletal regulatory protein, is involved in actin-based regulation of cell motility and adhesion, and contributes to tumor invasion and metastasis. However, the role of Mena in oral squamous cell carcinoma remains unclear. This is the first research focusing on the prognostic value of Mena in OSCC. In this study, we aimed to investigate the correlation between Mena expression and clinicopathological significance, as well as prognostic value in OSCC.

Methods

Mena gene expression profiles of OSCC and normal tissues were collected from Oncomine, TCGA, and GEO databases. Biological function was analyzed through GO, KEGG and GSEA enrichment. Further, the expression level of Mena and tumor-related markers in 151 OSCC specimens was examined by IHC staining ba

SUBMITTER: Na S 

PROVIDER: S-EPMC9822539 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature