Identification of miRNA-mRNA regulatory network associated with the glutamatergic system in post-traumatic epilepsy rats.

ABSTRACT:

Background

Glutamate is one of the most important excitatory neurotransmitters in the mammalian brain and is involved in a variety of neurological disorders. Increasing evidence also shows that microRNA (miRNA) and mRNA pairs are engaged in a variety of pathophysiological processes. However, the miRNA and mRNA pairs that affect the glutamatergic system in post-traumatic epilepsy (PTE) remain unknown.

Methods

PTE rats were induced by injecting 0.1 mol/L, 1 μL/min FeCl₂ solution. Behavioral scores and EEG monitoring were used to evaluate whether PTE was successfully induced. RNA-seq was used to obtain mRNA and miRNA expression profiles. Bioinformatics analysis was performed to screen differentially expressed mRNAs and miRNAs associated with the glutamatergic system

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9822725 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature