AIM™ platform: A new immunotherapy approach for viral diseases.

ABSTRACT: In addition to complications of acute diseases, chronic viral infections are linked to both malignancies and autoimmune disorders. Lack of adequate treatment options for Epstein-Barr virus (EBV), Human T-lymphotropic virus type 1 (HTLV-1), and human papillomavirus (HPV) remains. The NexImmune Artificial Immune Modulation (AIM) nanoparticle platform can be used to direct T cell responses by mimicking the dendritic cell function. In one application, AIM nanoparticles are used ex vivo to enrich and expand (E+E) rare populations of multi-antigen-specific CD8⁺ T cells for use of these cells as an AIM adoptive cell therapy. This study has demonstrated using E+E CD8⁺ T cells, the functional relevance of targeting EBV, HTLV-1, and HPV. Expanded T cells consist primarily of ef

SUBMITTER: Langan D 

PROVIDER: S-EPMC9822776 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature