Inhibition of platelet-surface-bound proteins during coagulation under flow II: Antithrombin and heparin.

ABSTRACT: Blood coagulation is a self-repair process regulated by activated platelet surfaces, clotting factors, and inhibitors. Antithrombin (AT) is one such inhibitor that impedes coagulation by targeting and inactivating several key coagulation enzymes. The effect of AT is greatly enhanced in the presence of heparin, a common anticoagulant drug. When heparin binds to AT, it either bridges with the target enzyme or induces allosteric changes in AT leading to more favorable binding with the target enzyme. AT inhibition of fluid-phase enzymes caused little suppression of thrombin generation in our previous mathematical models of blood coagulation under flow. This is because in that model, flow itself was a greater inhibitor of the fluid-phase enzymes than AT. From clinical observations, it is clear

SUBMITTER: Miyazawa K 

PROVIDER: S-EPMC9822793 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature