Genetically-predicted placental gene expression is associated with birthweight and adult body mass index.

ABSTRACT: The placenta is critical to human growth and development and has been implicated in health outcomes. Understanding the mechanisms through which the placenta influences perinatal and later-life outcomes requires further investigation. We evaluated the relationships between birthweight and adult body mass index (BMI) and genetically-predicted gene expression in human placenta. Birthweight genome-wide association summary statistics were obtained from the Early Growth Genetics Consortium (N = 298,142). Adult BMI summary statistics were obtained from the GIANT consortium (N = 681,275). We used S-PrediXcan to evaluate associations between the outcomes and predicted gene expression in placental tissue and, to identify genes where placental expression was exclusively associated with the outcomes,

SUBMITTER: Jasper EA 

PROVIDER: S-EPMC9822919 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature