A common IGF1R gene variant predicts later life breast cancer risk in women with preeclampsia.

ABSTRACT:

Purpose

Preeclampsia has been inconsistently associated with altered later life risk of cancer. This study utilizes the Nurses' Health Study 2 (NHS2) to determine if the future risk of breast and non-breast cancers in women who experience preeclampsia is modified by carrying a protective variant of rs2016347, a functional insulin-like growth factor receptor-1 (IGF1R) single nucleotide polymorphism.

Methods

This retrospective cohort study completed within the NHS2 evaluated participants enrolled in 1989 and followed them through 2015, with a study population of 86,751 after exclusions. Cox proportional hazards models both with and without the impact of rs2016347 genotype were used to assess the risk of invasive breast cancer, hormone receptor-positive (HR+) breast cancer, and

SUBMITTER: Powell M 

PROVIDER: S-EPMC9823040 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature