Influence of data acquisition modes and data analysis approaches on non-targeted analysis of phthalate metabolites in human urine.

ABSTRACT: Humans are often exposed to phthalates and their alternatives, on account of their widespread use in PVC as plasticizers, which are associated with harmful human effects. While targeted biomonitoring provides quantitative information for exposure assessment, only a small portion of phthalate metabolites has been targeted. This results in a knowledge gap in human exposure to other unknown phthalate compounds and their metabolites. Although the non-targeted analysis (NTA) approach is capable of screening a broad spectrum of chemicals, there is a lack of harmonized workflow in NTA to generate reproducible data within and between different laboratories. The objective of this study was to compare two different NTA data acquisition modes, the data-dependent (DDA) and independent (DIA) acquisitio

SUBMITTER: Feng YL 

PROVIDER: S-EPMC9823047 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature