DMyc-dependent upregulation of CD98 amino acid transporters is required for Drosophila brain tumor growth.

ABSTRACT: Tumor cells have an increased demand for nutrients to sustain their growth, but how these increased metabolic needs are ensured or how this influences tumor formation and progression remains unclear. To unravel tumor metabolic dependencies, particularly from extracellular metabolites, we have analyzed the role of plasma membrane metabolic transporters in Drosophila brain tumors. Using a well-established neural stem cell-derived tumor model, caused by brat knockdown, we have found that 13 plasma membrane metabolic transporters, including amino acid, carbohydrate and monocarboxylate transporters, are upregulated in tumors and are required for tumor growth. We identified CD98hc and several of the light chains with which it can form heterodimeric amino acid transporters, as crucial players in

SUBMITTER: Rebelo AR 

PROVIDER: S-EPMC9823048 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature