C-kit⁺VEGFR-2⁺ Mesenchymal Stem Cells Differentiate into Cardiovascular Cells and Repair Infarcted Myocardium after Transplantation.

ABSTRACT: Resent study suggests that c-kit⁺ cells in bone marrow-derived MSCs may differentiate toward cardiamyocytes. However, the properties of c-kit⁺ MSCs remain unclear. This study isolated c-kit⁺VEGFR-2⁺ cells from rat bone marrow-derived MSCs, and assessed potential of c-kit⁺VEGFR-2⁺ MSCs to differentiate towards cardiovascular cells and their efficiency of repairing the infarcted myocardium after transplantation. Gene expression profile of the cells was analyzed with RNA-sequencing. Potential of differentiation of the cells was determined after induction. Rat models of myocardial infarction were established by ligation of the left anterior descending coronary artery. The cells were treated with hypoxia and serum deprivation for

SUBMITTER: Zhou P 

PROVIDER: S-EPMC9823054 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature