Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto H
PROVIDER: S-EPMC9823215 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Yamamoto Hiroto H Uchida Yutaro Y Kurimoto Ryota R Chiba Tomoki T Matsushima Takahide T Ito Yoshiaki Y Inotsume Maiko M Miyata Kohei K Watanabe Kenta K Inada Masaki M Goshima Naoki N Uchida Tokujiro T Asahara Hiroshi H
The Journal of biological chemistry 20221209 1
Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates angiogenesis under hypoxic conditions. To investigate the posttranscriptional regulatory mechanism of HIF1α, we performed a cell-based screening to reveal potential cis-elements and the regulatory RNA-binding proteins that act as trans-factors. We found that LIN28A promoted HIF1α protein expression independently of the downregulation of microRNA let-7, which is also directly mediated by LIN28A. Transcriptome analysis an ...[more]