Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells.

ABSTRACT: Epithelial ovarian cancer (EOC) can originate from either fallopian tube epithelial (FTE) or ovarian surface epithelial (OSE) cells, but with different latencies and disease outcomes. To address the basis of these differences, we performed single cell RNA-sequencing of mouse cells isolated from the distal half of fallopian tube (FT) and surface layer of ovary. We find at the molecular level, FTE secretory stem/progenitor cells and OSE cells resemble mammary luminal progenitors and basal cells, respectively. An FT stromal subpopulation, enriched with Pdgfra ⁺ and Esr1 ⁺ cells, expresses multiple secreted factor (e.g., IGF1) and Hedgehog pathway genes and may serve as a niche for FTE cells. In contrast, Lgr5 ⁺ OSE cells express similar ge

SUBMITTER: Qin G 

PROVIDER: S-EPMC9823228 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature