Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila.

ABSTRACT: Some types of glia play an active role in neuronal signaling by modifying their activity although little is known about their role in sensory information signaling at the receptor level. In this research, we report a functional role for the glia that surround the soma of the olfactory receptor neurons (OSNs) in adult Drosophila. Specific genetic modifications have been targeted to this cell type to obtain live individuals who are tested for olfactory preference and display changes both increasing and reducing sensitivity. A closer look at the antenna by Ca²⁺ imaging shows that odor activates the OSNs, which subsequently produce an opposite and smaller effect in the glia that partially counterbalances neuronal activation. Therefore, these glia may play a dual role in preve

SUBMITTER: Calvin-Cejudo L 

PROVIDER: S-EPMC9823236 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature