Inhibition of Cancer Cell Proliferation and Bacterial Growth by Silver(I) Complexes Bearing a CH₃-Substituted Thiadiazole-Based Thioamide.

ABSTRACT: Ag(I) coordination compounds have recently attracted much attention as antiproliferative and antibacterial agents against a wide range of cancer cell lines and pathogens. The bioactivity potential of these complexes depends on their structural characteristics and the nature of their ligands. Herein, we present a series of four Ag(I) coordination compounds bearing as ligands the CH₃-substituted thiadiazole-based thioamide 5-methyl-1,3,4-thiadiazole-2-thiol (mtdztH) and phosphines, i.e., [AgCl(mtdztH)(PPh₃)₂] (1), [Ag(mtdzt)(PPh₃)₃] (2), [AgCl(mtdztH)(xantphos)] (3), and [AgmtdztH)(dppe)(NO₃)]_n (4), where xantphos = 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene and dppe = 1,2-bis(diphen

SUBMITTER: Varna D 

PROVIDER: S-EPMC9823356 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature