Crystallinity Dependence of PLLA Hydrophilic Modification during Alkali Hydrolysis.

ABSTRACT: Poly(L-lactic acid) (PLLA) has been extensively used in tissue engineering, in which its surface hydrophilicity plays an important role. In this work, an efficient and green strategy has been developed to tailor surface hydrophilicity via alkali hydrolysis. On one hand, the ester bond in PLLA has been cleaved and generates carboxyl and hydroxyl groups, both of which are beneficial to the improvement of hydrophilicity. On the other hand, the degradation of PLLA increases the roughness on the film surface. The resultant surface wettability of PLLA exhibits crucial dependence on its crystallinity. In the specimen with high crystallinity, the local enrichment of terminal carboxyl and hydroxyl groups in amorphous regions accelerates the degradation of ester group, producing more hydrophilic gro

SUBMITTER: Shi J 

PROVIDER: S-EPMC9823826 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature