Branched-Chain Amino Acids and Insulin Resistance, from Protein Supply to Diet-Induced Obesity.

ABSTRACT: For more than a decade, there has been a wide debate about the branched-chain amino acids (BCAA) leucine, valine, and isoleucine, with, on the one hand, the supporters of their anabolic effects and, on the other hand, those who suspect them of promoting insulin resistance. Indeed, the role of leucine in the postprandial activation of protein synthesis has been clearly established, even though supplementation studies aimed at taking advantage of this property are rather disappointing. Furthermore, there is ample evidence of an association between the elevation of their plasma concentrations and insulin resistance or the risk of developing type 2 diabetes, although there are many confounding factors, starting with the level of animal protein consumption. After a summary of their metabolism a

SUBMITTER: De Bandt JP 

PROVIDER: S-EPMC9824001 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature