Triterpene Derivatives from Garcinia oligantha and Their Anti-Cancer Activity.

ABSTRACT: Phytochemical investigations of leaves and twigs from Garcinia oligantha Merr. resulted in the isolation of five undescribed triterpene derivatives (1-5) and six known analogs (6-11). Their structures were determined based on extensive spectroscopic data and high-resolution mass spectra analyses. Compounds 1-11 were tested for their in vitro cytotoxicity against three human cancer cell lines (HeLa, HepG-2, and MCF-7). Compounds 1, 2, 8, and 11 exhibited broad and significant cytotoxicity against the tested cell lines with IC₅₀ values ranging from 5.04 to 21.55 μM. Compounds 5 and 9 showed cytotoxicity against HeLa and MCF-7 with IC₅₀ values ranging from 13.22 to 19.62 μM. The pr

SUBMITTER: Peng X 

PROVIDER: S-EPMC9824146 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature