Multifunctional Nanoparticles as High-Efficient Targeted Hypericin System for Theranostic Melanoma.

ABSTRACT: Biotin, spermine, and folic acid were covalently linked to the F127 copolymer to obtain a new drug delivery system designed for HY-loaded PDT treatment against B₁₆F₁₀ cells. Chemical structures and binders quantification were performed by spectroscopy and spectrophotometric techniques (¹NMR, HABA/Avidin reagent, fluorescamine assay). Critical micelle concentration, critical micelle temperature, size, polydispersity, and zeta potential indicate the hydrophobicity of the binders can influence the physicochemical parameters. Spermine-modified micelles showed fewer changes in their physical and chemical parameters than the F127 micelles without modification. Furthermore, zeta potential measurements suggest an increase in the physical stability of these carrier

SUBMITTER: de Morais FAP 

PROVIDER: S-EPMC9824163 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature