Circulating Extracellular Vesicles Are Increased in Newly Diagnosed Celiac Disease Patients.

ABSTRACT: Extracellular vesicles (EVs) are a class of circulating entities that are involved in intercellular crosstalk mechanisms, participating in homeostasis maintenance, and diseases. Celiac disease is a gluten-triggered immune-mediated disorder, characterized by the inflammatory insult of the enteric mucosa following local lymphocytic infiltration, resulting in villous atrophy. The goal of this research was the assessment and characterization of circulating EVs in celiac disease patients, as well as in patients already on an adequate gluten-free regimen (GFD). For this purpose, a novel and validated technique based on polychromatic flow cytometry that allowed the identification and enumeration of different EV sub-phenotypes was applied. The analysis evidenced that the total, annexin V+, leukocy

SUBMITTER: Efthymakis K 

PROVIDER: S-EPMC9824360 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature