Extensively Hydrolyzed Hypoallergenic Infant Formula with Retained T Cell Reactivity.

ABSTRACT:

Background

Immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) can be life-threatening and affects up to 3% of children. Hypoallergenic infant formulas based on hydrolyzed cow's milk protein are increasingly considered for therapy and prevention of cow's milk allergy. The aim of this study was to investigate the allergenic activity and ability to induce T cell and cytokine responses of an infant formula based on extensively hydrolyzed cow's milk protein (whey) (eHF, extensively hydrolyzed formula) supplemented with Galactooligosaccharides (GOS) and Limosilactobacillus fermentum CECT5716 (LF) to determine its suitability for treatment and prevention of CMA.

Methods

eHF and standard protein formula based on intact cow's milk proteins (iPF) with or without Galactool

SUBMITTER: Freidl R 

PROVIDER: S-EPMC9824366 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature