Zein Nanoparticles Containing Arginine-Phenylalanine-Based Surfactants: Stability, Antimicrobial and Hemolytic Activity.

ABSTRACT: Although cationic surfactants have a remarkable antimicrobial activity, they present an intrinsic toxicity that discourages their usage. In this work novel zein nanoparticles loaded with arginine-phenylalanine-based surfactants are presented. The nanoparticles were loaded with two single polar head (LAM and PNHC₁₂) and two with double amino acid polar head surfactants, arginine-phenylalanine (C₁₂PAM, PANHC₁₂). The formulations were characterized and their stability checked up to 365 days. Furthermore, the antimicrobial and hemolytic activities were investigated. Finally, NMR and molecular docking studies were carried out to elucidate the possible interaction mechanisms of surfactant-zein. The nanoparticles were obtained with satisfactory size, zeta potentia

SUBMITTER: Perez L 

PROVIDER: S-EPMC9824401 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature