Gene signature and prognostic value of ubiquitination-related genes in endometrial cancer.

ABSTRACT: Protein ubiquitination is closely related to tumor occurrence and development. The specific role of ubiquitination in endometrial cancer remains largely unclear. Therefore, we constructed a novel endometrial cancer prognostic model based on ubiquitination-related genes. We extracted the expression matrices of ubiquitination-related genes from the Cancer Genome Atlas database, upon which we performed univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses to obtain 22 ubiquitination-related genes for the construction of the prognostic model. Survival, regression, clinical correlation, and principal component analyses were performed to assess the performance of the model. Drug sensitivity analysis was performed based on these ubiquitination-r

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9824913 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature