Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behcet's disease.

ABSTRACT:

Background

Behçet's disease (BD) is a systemic inflammatory disease that involves various organs. The clinical manifestation-based diagnosis of BD is a time-consuming process, which makes it difficult to distinguish from patients with similar symptoms. Moreover, an authentic biomarker has not been developed for accurate diagnosis yet. Our current study investigated the unique metabolic signatures of BD and explored biomarkers for precise diagnosis based on an untargeted metabolomic approach.

Methods

Integrative metabolomic and lipidomic profiling was performed on plasma samples of BD patients (n = 40), healthy controls (HCs, n = 18), and disease controls (DCs, n = 17) using GC-TOF MS and LC-Orbitrap MS. Additionally, the lipid profiles of 66 peripheral blood mononuclear cell

SUBMITTER: Park SJ 

PROVIDER: S-EPMC9824930 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature