Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.

ABSTRACT:

Background

Prevention of pregnancy-related alloimmunization and the management of hemolytic disease of the fetus and newborn (HDFN) has significantly improved over the past decades. Considering improvements in HDFN care, the objectives of this systematic literature review were to assess the prenatal treatment landscape and outcomes of Rh(D)- and K-mediated HDFN in mothers and fetuses, to identify the burden of disease, to identify evidence gaps in the literature, and to provide recommendations for future research.

Methods

We performed a systematic search on MEDLINE, EMBASE and clinicaltrials.gov. Observational studies, trials, modelling studies, systematic reviews of cohort studies, and case reports and series of women and/or their fetus with HDFN caused by Rhesus (Rh)D or K

SUBMITTER: de Winter DP 

PROVIDER: S-EPMC9824959 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature