Who's afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data.

ABSTRACT:

Background

Many human disease phenotypes manifest differently by sex, making the development of methods for incorporating X and Y-chromosome data into analyses vital. Unfortunately, X and Y chromosome data are frequently excluded from large-scale analyses of the human genome and epigenome due to analytical complexity associated with sex chromosome dosage differences between XX and XY individuals, and the impact of X-chromosome inactivation (XCI) on the epigenome. As such, little attention has been given to considering the methods by which sex chromosome data may be included in analyses of DNA methylation (DNAme) array data.

Results

With Illumina Infinium HumanMethylation450 DNAme array data from 634 placental samples, we investigated the effects of probe filtering, normaliza

SUBMITTER: Inkster AM 

PROVIDER: S-EPMC9825011 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature