Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function.

ABSTRACT: Using Drosophila melanogaster (fruit fly) as a model organism has ensured significant progress in many areas of biological science, from cellular organization and genomic investigations to behavioral studies. Due to the accumulated scientific knowledge, in recent years, Drosophila was brought to the field of modeling human diseases, including heart disorders. The presented work describes the experimental system for monitoring and manipulating the heart function in the context of a whole live organism using red light (617 nm) and without invasive procedures. Control over the heart was achieved using optogenetic tools. Optogenetics combines the expression of light-sensitive transgenic opsins and their optical activation to regulate the biological tissue of interest. In this work, a custom in

SUBMITTER: Gracheva E 

PROVIDER: S-EPMC9825051 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature