Outcomes associated with antiphospholipid antibodies in COVID-19: A prospective cohort study.

ABSTRACT:

Background

The significance of antiphospholipid antibodies (aPL) in COVID-19 remains uncertain.

Objectives

We determined whether aPL are associated with COVID-19 and/or thrombosis or adverse outcomes during hospitalization for COVID-19.

Methods

Symptomatic adults tested for SARS-CoV-2 for clinical reasons (March-July 2020) with either ≥1 positive polymerase chain reaction (COVID-19+) or all negative (non-COVID-19) results were recruited to a biobank collecting plasma, clinical data, and outcomes. We tested baseline plasma samples (days 0-7) of all subjects (and day-30 samples in the COVID-19+ subjects, when available) for aPL (anticardiolipin immunoglobulin [Ig]M/IgG, anti-β2-glycoprotein I IgM/IgG, antiphosphatidylserine/prothrombin IgM/IgG, and lupus anticoagulant).

SUBMITTER: Mendel A 

PROVIDER: S-EPMC9825139 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature