Identification of Oxidative Stress-Related Biomarkers in Diabetic Kidney Disease.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease throughout the world. In kidney disease, oxidative stress has been linked to both antioxidant depletions and increased reactive oxygen species (ROS) production. Thus, the objective of this study was to identify biomarkers related to oxidative stress in DKD.

Methods

The gene expression profile of the DKD was extracted from the Gene Expression Omnibus (GEO) database. The identification of the differentially expressed genes (DEGs) was performed using the "limma" R package, and weighted gene coexpression network analysis (WGCNA) was used to find the gene modules that were most related to DKD. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analys

SUBMITTER: Ma X 

PROVIDER: S-EPMC9825216 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature