Prognostic Value of Colonic Tissue and Blood Eosinophils in Ulcerative Colitis.

ABSTRACT:

Background

It has been suggested that eosinophils may be a prognostic marker of disease outcome in ulcerative colitis (UC), but conflicting data exist. The objective was to investigate the extent of mucosal eosinophils and peripheral blood eosinophil count in newly diagnosed UC patients and to investigate its predictive value in short- and long-term disease outcomes.

Methods

The degree of eosinophilia in baseline colonic biopsies and blood of newly diagnosed UC patients was retrospectively analyzed. It was investigated if tissue and blood eosinophilia could be a marker of a severe phenotype of UC, defined as the need for corticosteroids or immunomodulators in the first year or treatment with therapeutic monoclonal antibodies or colectomy during follow-up. Time to therapeutic

SUBMITTER: Haasnoot ML 

PROVIDER: S-EPMC9825288 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature