Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis.

ABSTRACT:

Background

Numerous studies have examined the gut microbial ecology of patients with Crohn's disease (CD) and ulcerative colitis, but inflammatory bowel disease-associated taxa and ecological effect sizes are not consistent between studies.

Methods

We systematically searched PubMed and Google Scholar and performed a meta-analysis of 13 studies to analyze how variables such as sample type (stool, biopsy, and lavage) affect results in inflammatory bowel disease gut microbiome studies, using uniform bioinformatic methods for all primary data.

Results

Reduced alpha diversity was a consistent feature of both CD and ulcerative colitis but was more pronounced in CD. Disease contributed significantly variation in beta diversity in most studies, but effect size varied, and the

SUBMITTER: Abdel-Rahman LIH 

PROVIDER: S-EPMC9825291 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature