Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients.

ABSTRACT: Pathologically increased beta power has been described as a biomarker for Parkinson's disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we investigate the association between subthalamic beta dynamics and motor impairment in a cohort of 106 Parkinson's patients in the ON- and OFF-medication state, using two different methods of beta burst determination. We report a frequency-specific correlation of low beta power and burst duration with motor impairment OFF dopaminergic medication. Furthermore, reduction of power and burst duration correlated significantly with symptom alleviation through dopaminergic medication. Importantly, qualitatively similar results were yielded with two different methods of beta burst definition. Our findings validate the robust

SUBMITTER: Lofredi R 

PROVIDER: S-EPMC9825387 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature