Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers.

ABSTRACT: Inflammation has long been recognized to contribute to cancer development, particularly across the gastrointestinal tract. Patients with inflammatory bowel disease have an increased risk for bowel cancers, and it has been posited that a field of genetic changes may underlie this risk. Here, we define the clinical features, genomic landscape, and germline alterations in 174 patients with colitis-associated cancers and sequenced 29 synchronous or isolated dysplasia. TP53 alterations, an early and highly recurrent event in colitis-associated cancers, occur in half of dysplasia, largely as convergent evolution of independent events. Wnt pathway alterations are infrequent, and our data suggest transcriptional rewiring away from Wnt. Sequencing of multiple dysplasia/cancer lesions from mouse mod

SUBMITTER: Chatila WK 

PROVIDER: S-EPMC9825391 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature