QTLbase2: an enhanced catalog of human quantitative trait loci on extensive molecular phenotypes.

ABSTRACT: Deciphering the fine-scale molecular mechanisms that shape the genetic effects at disease-associated loci from genome-wide association studies (GWAS) remains challenging. The key avenue is to identify the essential molecular phenotypes that mediate the causal variant and disease under particular biological conditions. Therefore, integrating GWAS signals with context-specific quantitative trait loci (QTLs) (such as different tissue/cell types, disease states, and perturbations) from extensive molecular phenotypes would present important strategies for full understanding of disease genetics. Via persistent curation and systematic data processing of large-scale human molecular trait QTLs (xQTLs), we updated our previous QTLbase database (now QTLbase2, http://mulinlab.org/qtlbase) to comprehen

SUBMITTER: Huang D 

PROVIDER: S-EPMC9825467 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature